product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Filaggrin Antibody
catalog :
MBS8243034
quantity :
0.03 mL
price :
155 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS8243034 image 1
Western blot analysis of Filaggrin expression in HeLa (A), NS-1 (B), PC12 (C) whole cell lysates.
product information
catalog number :
MBS8243034
products type :
Antibody
products full name :
Anti-Filaggrin Antibody
products short name :
[Filaggrin]
products name syn :
[Filaggrin]
other names :
[Filaggrin; Filaggrin; filaggrin; filaggrin]
products gene name :
[FLG]
other gene names :
[FLG; FLG; ATOD2]
uniprot entry name :
FILA_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
4061
specificity :
Recognizes endogenous levels of Filaggrin protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
storage stability :
Shipping: Blue Ice. Upon delivery aliquot and store at - 20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
Western Blot: (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Filaggrin. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to Filaggrin
ncbi gi num :
84028206
ncbi acc num :
P20930.3
uniprot acc num :
P20930
ncbi pathways :
AhR Pathway (755436)
ncbi summary :
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
uniprot summary :
FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: intermediate filament; intracellular membrane-bound organelle; nucleus. Molecular Function: calcium ion binding; protein binding; structural molecule activity. Biological Process: keratinocyte differentiation; multicellular organismal development. Disease: Dermatitis, Atopic, 2; Ichthyosis Vulgaris
size1 :
0.03 mL
price1 :
155 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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