Anti-GLP-1 Receptor Antibody | MyBioSource MBS8242808 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-GLP-1 Receptor Antibody

catalog :

MBS8242808

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of GLP-1 Receptor expression in mouse brain (A), rat brain (B) whole cell lysates.

image 2 :

Immunohistochemical analysis of GLP-1 Receptor staining in human pancreas formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8242808

products type :

Antibody

products full name :

Anti-GLP-1 Receptor Antibody

products short name :

[GLP-1 Receptor]

products name syn :

[Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R]

other names :

[Glucagon-like peptide 1 receptor; Glucagon-like peptide 1 receptor; glucagon-like peptide 1 receptor; glucagon like peptide 1 receptor]

products gene name :

[GLP1R]

other gene names :

[GLP1R; GLP1R; GLP-1; GLP-1R; GLP-1-R; GLP-1 receptor; GLP-1-R; GLP-1R]

uniprot entry name :

GLP1R_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

463

specificity :

Recognizes endogenous levels of GLP-1 Receptor protein.

purity :

The antibody was purified by affinity chromatography.

form :

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence of human GLP-1 Receptor. The exact sequence is proprietary.

products description :

Rabbit polyclonal to GLP-1 Receptor

ncbi gi num :

311033387

ncbi acc num :

P43220.2

uniprot acc num :

P43220

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (1269570); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class B Secretin-like Pathway (198781); Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway (1270107); Glucagon-type Ligand Receptors Pathway (1269572); Insulin Secretion Pathway (777534); Integration Of Energy Metabolism Pathway (1270101); Metabolism Pathway (1269956)

ncbi summary :

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

uniprot summary :

GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytosol; integral to membrane; intracellular; plasma membrane. Molecular Function: glucagon receptor activity; protein binding; transmembrane receptor activity. Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; learning and/or memory; positive regulation of blood pressure; regulation of heart contraction; regulation of insulin secretion; response to stress

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage