Anti-NGF beta Antibody | MyBioSource MBS8242378 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-NGF beta Antibody

catalog :

MBS8242378

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of NGF beta expression in Raji (A), HepG2 (B) whole cell lysates.

product information

catalog number :

MBS8242378

products type :

Antibody

products full name :

Anti-NGF beta Antibody

products short name :

[NGF beta]

products name syn :

[NGFB; Beta-nerve growth factor; Beta-NGF]

other names :

[Beta-nerve growth factor; Beta-nerve growth factor; beta-nerve growth factor; nerve growth factor]

products gene name :

[NGF]

other gene names :

[NGF; NGF; NGFB; HSAN5; Beta-NGF; NGFB; Beta-NGF]

uniprot entry name :

NGF_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Bovine, Pig

sequence length :

241

specificity :

Recognizes endogenous levels of NGF beta protein.

purity :

The antibody was purified by affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

Western Blot: (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NGF beta. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to NGF beta

ncbi gi num :

90110037

ncbi acc num :

P01138.3

uniprot acc num :

P01138

ncbi mol weight :

26,959 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Activation Of TRKA Receptors Pathway (1269461); Apoptosis Pathway (83060); Apoptosis Pathway (470); Axonal Growth Stimulation Pathway (1269457); BDNF Signaling Pathway (712093); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (1269447); Ceramide Signalling Pathway (1269455); Frs2-mediated Activation Pathway (1269470); Id Signaling Pathway (198871)

ncbi summary :

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

uniprot summary :

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: cytoplasmic membrane-bound vesicle; endosome; extracellular region; Golgi lumen. Molecular Function: growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; receptor signaling protein activity. Biological Process: activation of MAPKK activity; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; neuron apoptosis; peripheral nervous system development; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of apoptosis; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of collateral sprouting; positive regulation of neuron maturation; positive regulation of protein ubiquitination; Ras protein signal transduction; regulation of axonogenesis; regulation of caspase activity; regulation of neuron differentiation; regulation of neurotransmitter secretion; regulation of release of sequestered calcium ion into cytosol; sensory perception of pain; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage