Anti-MT-ND5 Antibody | MyBioSource MBS8242338 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-MT-ND5 Antibody

catalog :

MBS8242338

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow, zebrafish

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of MT-ND5 expression in K562 (A), Hela (B), mouse kidney (C) whole cell lysates.

product information

catalog number :

MBS8242338

products type :

Antibody

products full name :

Anti-MT-ND5 Antibody

products short name :

[MT-ND5]

products name syn :

[MTND5; NADH5; ND5; NADH-ubiquinone oxidoreductase chain 5; NADH dehydrogenase subunit 5]

other names :

[NADH-ubiquinone oxidoreductase chain 5; NADH-ubiquinone oxidoreductase chain 5; NADH dehydrogenase, subunit 5 (complex I); mitochondrially encoded NADH dehydrogenase 5; NADH dehydrogenase subunit 5]

products gene name :

[MT-ND5]

other gene names :

[MT-ND5; MT-ND5; MTND5; ND5; MTND5; NADH5; ND5]

uniprot entry name :

NU5M_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep, Zebrafish

sequence length :

603

specificity :

Recognizes endogenous levels of MT-ND5 protein.

purity :

The antibody was purified by affinity chromatography.

form :

Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% Sodium Azide.

storage stability :

Shipped and store at 4 degree C for one year. Do not freeze.

tested application :

Western Blot (WB), Immunoprecipitation (IP)

app notes :

Western Blot: (1/500 - 1/1000); Immunoprecipitation: (1/10 - 1/100)

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MT-ND5. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to MT-ND5

ncbi gi num :

6648059

ncbi acc num :

P03915.2

uniprot acc num :

P03915

ncbi mol weight :

67,027 Da

ncbi pathways :

Complex I Biogenesis Pathway (1339146); Electron Transport Chain Pathway (198860); Metabolic Pathways (132956); Metabolism Pathway (1269956); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (413406); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (890440); Oxidative Phosphorylation Pathway (198870); Oxidative Phosphorylation Pathway (82942); Oxidative Phosphorylation Pathway (303); Parkinson's Disease Pathway (83098)

uniprot summary :

MT-ND5: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND5 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND5 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ND5 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Defects in MT-ND5 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS). MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Belongs to the complex I subunit 5 family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; EC 1.6.5.3; Mitochondrial. Chromosomal Location of Human Ortholog: -. Disease: Leber Optic Atrophy; Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage