catalog number :
MBS8242091
products full name :
Anti-CD49c Antibody
products short name :
[CD49c]
products name syn :
[MSK18; Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c]
other names :
[Integrin alpha-3; Integrin alpha-3; integrin alpha-3; integrin subunit alpha 3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3]
products gene name :
[ITGA3]
other gene names :
[ITGA3; ITGA3; VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3; MSK18; GAPB3]
uniprot entry name :
ITA3_HUMAN
reactivity :
Human, Mouse
specificity :
Recognizes endogenous levels of CD49c protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
storage stability :
Shipped at 4°C.Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
Western Blot: (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD49c. The exact sequence is proprietary.
other info2 :
. Source: Rabbit
products description :
Rabbit polyclonal antibody to CD49c
ncbi pathways :
Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Basigin Interactions Pathway (1269376); CXCR4-mediated Signaling Events Pathway (137910); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)
ncbi summary :
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
uniprot summary :
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.