catalog number :
MBS8242046
products full name :
Anti-GBP1 Antibody
products short name :
[GBP1]
products name syn :
[Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1]
other names :
[Guanylate-binding protein 1; Guanylate-binding protein 1; guanylate-binding protein 1; guanylate binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1]
products gene name :
[GBP1]
other gene names :
[GBP1; GBP1; GBP-1; HuGBP-1]
uniprot entry name :
GBP1_HUMAN
reactivity :
Human, Rat, Bovine
specificity :
Recognizes endogenous levels of GBP1 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
storage stability :
Shipping: Blue Ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
Western Blot: (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GBP1. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to GBP1
ncbi pathways :
Cytokine Signaling In Immune System Pathway (1269310); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Gamma Signaling Pathway (1269314); Type II Interferon Signaling (IFNG) Pathway (198918)
ncbi summary :
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
uniprot summary :
GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3. Protein type: Hydrolase; Cell adhesion; Vesicle. Chromosomal Location of Human Ortholog: 1p22.2. Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane. Molecular Function: actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding. Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling