Anti-CD122 Antibody | MyBioSource MBS8241964 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD122 Antibody

catalog :

MBS8241964

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of CD122 expression in Jurkat (A), mouse brain (B), PC12 (C) whole cell lysates.

image 2 :

Immunohistochemical analysis of CD122 staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8241964

products type :

Antibody

products full name :

Anti-CD122 Antibody

products short name :

[CD122]

products name syn :

[Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; p75; CD122]

other names :

[Interleukin-2 receptor subunit beta; Interleukin-2 receptor subunit beta; interleukin-2 receptor subunit beta; interleukin 2 receptor subunit beta; High affinity IL-2 receptor subunit beta; p70-75; p75; CD_antigen: CD122]

products gene name :

[IL2RB]

other gene names :

[IL2RB; IL2RB; CD122; IL15RB; P70-75; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; p75]

uniprot entry name :

IL2RB_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Monkey

sequence length :

551

specificity :

Recognizes endogenous levels of CD122 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

storage stability :

Ships on blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western Blot: (1/500 - 1/1000). Immunohistochemistry: (1/100 - 1/200)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD122. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to CD122

ncbi gi num :

124321

ncbi acc num :

P14784.1

uniprot acc num :

P14784

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Axon Guidance Pathway (1270303); Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Downstream Signal Transduction Pathway (1269479); Downstream Signaling In Naive CD8+ T Cells Pathway (138018)

ncbi summary :

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

uniprot summary :

IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: external side of plasma membrane; integral to plasma membrane; intracellular; membrane; plasma membrane. Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; protein binding. Biological Process: activation of MAPKK activity; axon guidance; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; protein complex assembly; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; viral reproduction

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage