Anti-UCP3 Antibody | MyBioSource MBS8241764 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-UCP3 Antibody

catalog :

MBS8241764

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of UCP3 expression in L929 (A), rat kidney (B) whole cell lysates.

product information

catalog number :

MBS8241764

products type :

Antibody

products full name :

Anti-UCP3 Antibody

products short name :

[UCP3]

products name syn :

[SLC25A9; Mitochondrial uncoupling protein 3; UCP 3; Solute carrier family 25 member 9]

other names :

[Mitochondrial uncoupling protein 3; Mitochondrial uncoupling protein 3; mitochondrial uncoupling protein 3; uncoupling protein 3 (mitochondrial, proton carrier); Solute carrier family 25 member 9]

products gene name :

[UCP3]

other gene names :

[UCP3; UCP3; SLC25A9; SLC25A9; UCP 3]

uniprot entry name :

UCP3_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Dog, Pig

sequence length :

312

specificity :

Recognizes endogenous levels of UCP3 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

storage stability :

Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

Western Blot: (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human UCP3. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to UCP3

ncbi gi num :

2497983

ncbi acc num :

P55916.1

uniprot acc num :

P55916

ncbi pathways :

Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Electron Transport Chain Pathway (198860); Energy Metabolism Pathway (198907); Metabolism Pathway (1269956); Mitochondrial Uncoupling Proteins Pathway (1270130); Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway (1270127); The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway (1270121); The Fatty Acid Cycling Model Pathway (1270131); The Proton Buffering Model Pathway (1270132)

ncbi summary :

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

uniprot summary :

UCP3: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. Defects in UCP3 may be involved in obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral; Transporter. Chromosomal Location of Human Ortholog: 11q13.4. Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion. Molecular Function: oxidative phosphorylation uncoupler activity; protein binding; structural constituent of ribosome; transporter activity. Biological Process: aging; cellular metabolic process; cellular response to hormone stimulus; fatty acid metabolic process; lipid metabolic process; mitochondrial transport; proton transport; respiratory gaseous exchange; response to activity; response to cold; response to glucocorticoid stimulus; response to hypoxia; response to insulin stimulus; response to nutrient; response to superoxide; translation. Disease: Obesity

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage