protein

DBI Blocking Peptide

MBS8240284

1 mg

160 USD

Blocking Peptide

DBI Blocking Peptide

[DBI]

[Acyl-CoA-binding protein; ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP]

[acyl-CoA-binding protein isoform 3; Acyl-CoA-binding protein; acyl-CoA-binding protein; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); Diazepam-binding inhibitor; DBI; Endozepine; EP]

[DBI]

[DBI; DBI; EP; ACBP; ACBD1; CCK-RP; ACBP; DBI; EP]

ACBP_HUMAN

Human, Mouse, Rat, Porcine

87

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Blocking (BL)

Source: Synthetic. Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

The peptide is used to block Anti-DBI Antibody reactivity.

120433590

NP_001073331.1

NM_001079862.2

P07108

13,911 Da

PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); SREBP Signalling Pathway (219802)

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 2q12-q21. Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum. Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding. Biological Process: protein palmitoylation; triacylglycerol metabolic process; behavioral fear response; learning and/or memory; hair follicle development; transport; lateral ventricle development

1 mg

160 USD

5 mg

305