protein

PMEPA1 Blocking Peptide

MBS824023

1 mg

160 USD

Blocking Peptide

PMEPA1 Blocking Peptide

[PMEPA1]

[STAG1; TMEPAI; Transmembrane prostate androgen-induced protein; Solid tumor-associated 1 protein]

[protein TMEPAI isoform d; Protein TMEPAI; protein TMEPAI; solid tumor-associated 1 protein; transmembrane, prostate androgen induced RNA; prostate transmembrane protein androgen induced 1; prostate transmembrane protein, androgen induced 1; Prostate transmembrane protein androgen induced 1; Solid tumor-associated 1 protein; Transmembrane prostate androgen-induced protein]

[PMEPA1]

[PMEPA1; PMEPA1; STAG1; TMEPAI; STAG1; TMEPAI]

PMEPA_HUMAN

Synthetic

Human

259

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-PMEPA1 Antibody reactivity.

364023812

NP_001242905.1

NM_001255976.1

P82673

Disease Pathway (530764); Downregulation Of TGF-beta Receptor Signaling Pathway (645293); Loss Of Function Of SMAD2/3 In Cancer Pathway (906019); Loss Of Function Of SMAD4 In Cancer Pathway (906017); Loss Of Function Of TGFBR1 In Cancer Pathway (906025); Loss Of Function Of TGFBR2 In Cancer Pathway (906022); SMAD2/3 MH2 Domain Mutants In Cancer Pathway (906021); SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway (906020); SMAD4 MH2 Domain Mutants In Cancer Pathway (906018); Signal Transduction Pathway (477114)

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

TMEPAI: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Belongs to the PMEPA1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 20q13.31-q13.33. Cellular Component: Golgi membrane; early endosome membrane; integral to membrane; plasma membrane; endosome membrane. Molecular Function: protein binding; WW domain binding. Biological Process: transforming growth factor beta receptor signaling pathway; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway

1 mg

160 USD

5 mg

305