GSK3 beta Blocking Peptide | MyBioSource MBS8239742 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

GSK3 beta Blocking Peptide

catalog :

MBS8239742

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8239742

products type :

Blocking Peptide

products full name :

GSK3 beta Blocking Peptide

products short name :

[GSK3 beta]

products name syn :

[Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B]

other names :

[glycogen synthase kinase-3 beta isoform 2; Glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)]

products gene name :

[GSK3B]

other gene names :

[GSK3B; GSK3B; GSK-3 beta]

uniprot entry name :

GSK3B_HUMAN

reactivity :

Human, Mouse, Rat, Bovine, Porcine, Sheep, Zebrafish

sequence length :

420

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipped at 4°C. Store at -20°C for one year.

tested application :

Blocking (BL)

other info1 :

. Source: Synthetic

other info2 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.

products description :

The peptide is used to block Anti-GSK3 beta Antibody reactivity.

ncbi gi num :

225903437

ncbi acc num :

NP_001139628.1

ncbi gb acc num :

NM_001146156.1

uniprot acc num :

P49841

ncbi pathways :

AKT Phosphorylates Targets In The Cytosol Pathway (1269189); AMER1 Mutants Destabilize The Destruction Complex Pathway (1268913); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1268909); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1268912); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1268910); Adaptive Immune System Pathway (1269171); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Androgen Receptor Signaling Pathway (198806)

ncbi summary :

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation. Protein type: Protein kinase, CMGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.26; CMGC group; GSK family; GSK subfamily. Chromosomal Location of Human Ortholog: 3q13.3. Cellular Component: nucleoplasm; centrosome; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; dendritic spine; plasma membrane; dendritic shaft; ribonucleoprotein complex; cytosol; beta-catenin destruction complex; nucleus; lipid raft. Molecular Function: integrin binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; NF-kappaB binding; protein binding; p53 binding; ubiquitin protein ligase binding; tau-protein kinase activity; beta-catenin binding; kinase activity; tau protein binding; protein kinase binding; ATP binding. Biological Process: circadian rhythm; fat cell differentiation; glycogen metabolic process; negative regulation of MAP kinase activity; axon guidance; genetic imprinting; re-entry into mitotic cell cycle; nerve growth factor receptor signaling pathway; positive regulation of protein binding; positive regulation of axon extension; protein amino acid autophosphorylation; response to lithium ion; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; positive regulation of cell-matrix adhesion; negative regulation of protein binding; myoblast fusion; ER overload response; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; response to drug; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of neuron maturation; peptidyl-serine phosphorylation; organ morphogenesis; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage