EPHA2 Blocking Peptide | MyBioSource MBS823928 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

EPHA2 Blocking Peptide

catalog :

MBS823928

quantity :

1 mg

price :

195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS823928

products type :

Blocking Peptide

products full name :

EPHA2 Blocking Peptide

products short name :

[EPHA2]

products name syn :

[ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK]

other names :

[ephrin type-A receptor 2; Ephrin type-A receptor 2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; EPH receptor A2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK]

products gene name :

[EPHA2]

other gene names :

[EPHA2; EPHA2; ECK; CTPA; ARCC2; CTPP1; CTRCT6; ECK]

uniprot entry name :

EPHA2_HUMAN

reactivity :

Human, Mouse, Rat, Monkey

sequence length :

976

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipped at 4 degree C. Store at -20 degree C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

other info1 :

Source: Synthetic. Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

products description :

The peptide is used to block Anti-EPHA2 Antibody reactivity.

ncbi gi num :

32967311

ncbi acc num :

NP_004422.2

ncbi gb acc num :

NM_004431.3

uniprot acc num :

P29317

ncbi mol weight :

54,305 Da

ncbi pathways :

Arf6 Signaling Events Pathway (138034); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Direct P53 Effectors Pathway (137939); EPH-Ephrin Signaling Pathway (1016174); EPH-ephrin Mediated Repulsion Of Cells Pathway (1016178); EPHA Forward Signaling Pathway (138041); EPHA-mediated Growth Cone Collapse Pathway (1016175)

ncbi summary :

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

uniprot summary :

EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice. Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; TK group; Eph family. Chromosomal Location of Human Ortholog: 1p36. Cellular Component: focal adhesion; cell surface; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: neural tube development; axon guidance; peptidyl-tyrosine phosphorylation; viral reproduction; multicellular organismal development; notochord formation; osteoclast differentiation; bone remodeling; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; protein kinase B signaling cascade; angiogenesis; vasculogenesis; cell adhesion; skeletal development; axial mesoderm formation; cell migration; negative regulation of protein kinase B signaling cascade; mammary gland epithelial cell proliferation; regulation of angiogenesis; osteoblast differentiation; keratinocyte differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; notochord cell development. Disease: Cataract 6, Multiple Types

size1 :

1 mg

price1 :

195 USD

size2 :

5 mg

price2 :

435

more info or order :

MyBioSource product webpage