protein

SHOX Blocking Peptide

MBS823728

1 mg

160 USD

Blocking Peptide

SHOX Blocking Peptide

[SHOX]

[PHOG; Short stature homeobox protein; Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein]

[short stature homeobox protein isoform SHOXa; Short stature homeobox protein; short stature homeobox protein; growth control factor, X-linked; pseudoautosomal homeobox-containing osteogenic protein; short stature homeobox; Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein]

[SHOX]

[SHOX; SHOX; SS; GCFX; PHOG; SHOXY; PHOG]

SHOX_HUMAN

Synthetic

Human, Mouse, Chicken, Dog

292

>85%

Lyophilized powder

Shipped at 4°C. Store at -20°C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-SHOX Antibody (MBS820336) reactivity.

4506943

NP_000442.1

NM_000451.3

O15266

This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

SHOX: Controls fundamental aspects of growth and development. Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD). LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna. Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD). LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date. Defects in SHOX are a cause of idiopathic short stature (ISS). Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: Xp22.33;Yp11.3. Cellular Component: nucleus. Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; skeletal development. Disease: Short Stature, Idiopathic, X-linked; Langer Mesomelic Dysplasia; Short Stature, Idiopathic, Autosomal; Leri-weill Dyschondrosteosis

1 mg

160 USD

5 mg

305