catalog number :
MBS823638
products type :
Blocking Peptide
products full name :
Cytokeratin 5 Blocking Peptide
products short name :
[Cytokeratin 5]
products name syn :
[Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5]
other names :
[keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5; 58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5]
products gene name :
[KRT5]
other gene names :
[KRT5; KRT5; K5; CK5; DDD; DDD1; EBS2; KRT5A; CK-5; K5]
uniprot entry name :
K2C5_HUMAN
reactivity :
Human, Mouse, Rat, Bovine, Pig
form :
Lyophilized powder
storage stability :
Shipped at 4°C. Store at -20°C for one year.
tested application :
Blocking (BL)
app notes :
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.
other info1 :
Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
products description :
The peptide is used to block Anti-Cytokeratin 5 Antibody reactivity.
ncbi acc num :
NP_000415.2
ncbi gb acc num :
NM_000424.3
ncbi pathways :
Glucocorticoid Receptor Regulatory Network Pathway (138014)
ncbi summary :
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
uniprot summary :
K5: Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13.13. Cellular Component: membrane; mitochondrion; cytoplasm; keratin filament; plasma membrane; intermediate filament; nucleus; cytosol. Molecular Function: protein binding; structural constituent of cytoskeleton. Biological Process: hemidesmosome assembly; epidermis development. Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dowling-degos Disease 1; Epidermolysis Bullosa Simplex With Migratory Circinate Erythema; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex With Mottled Pigmentation; Epidermolysis Bullosa Simplex, Dowling-meara Type