catalog number :
MBS8233912
products full name :
Anti-SLK Antibody
products short name :
SLK
products name syn :
KIAA0204; STK2; STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2
other names :
STE20-like serine/threonine-protein kinase isoform 2; STE20-like serine/threonine-protein kinase; STE20-like serine/threonine-protein kinase; STE20-like kinase; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2
other gene names :
SLK; SLK; LOSK; STK2; se20-9; bA16H23.1; KIAA0204; STK2; STE20-like kinase; hSLK; STE20-related kinase
uniprot entry name :
SLK_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Recognizes endogenous levels of SLK protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
app notes :
WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF (1/100 - 1/500), ICC (1/100 - 1/500)
other info1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SLK. The exact sequence is proprietary.
other info2 :
Entrez Gene: 9748 (Human); 20874 (Mouse); 54308 (Rat) . SwissProt: Q9H2G2 (Human); O54988 (Mouse); O08815 (Rat)
products description :
Rabbit polyclonal antibody to SLK
ncbi acc num :
NP_001291672.1
ncbi gb acc num :
NM_001304743.1
ncbi mol weight :
138,996 Da
ncbi pathways :
Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872)
uniprot summary :
SLK: a microtubule-associated protein kinase required for progression through G2. Co-localizes with the mitotic spindle in cells undergoing mitosis. Regulates actin reorganization during cell adhesion and spreading via a Rac1-mediated pathway. Signals via ASK1 and p38 to promote apoptosis. Activated in response to anoxia and ischemia-reperfusion injury in cell culture. It inhibits the protective aspects of the endoplasmic reticulum stress response, thus contributing to its proapoptotic effect. Two alternatively-spliced isoforms have been described. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; STE group; STE20 family; SLK subfamily. Chromosomal Location of Human Ortholog: 10q24.33. Cellular Component: cytoplasm. Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein homodimerization activity; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: apoptosis; protein amino acid autophosphorylation