product summary
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company name :
MyBioSource
product type :
protein
product name :
Integrin alpha 7 LC Blocking Peptide
catalog :
MBS823191
quantity :
1 mg
price :
160 USD
more info or order :
product information
catalog number :
MBS823191
products type :
Blocking Peptide
products full name :
Integrin alpha 7 LC Blocking Peptide
products short name :
[Integrin alpha 7 LC]
products name syn :
[Integrin alpha-7]
other names :
[integrin alpha-7 isoform 1; Integrin alpha-7; integrin alpha-7; integrin alpha 7 chain; integrin, alpha 7]
products gene name :
[ITGA7]
other gene names :
[ITGA7; ITGA7]
uniprot entry name :
ITA7_HUMAN
host :
Synthetic
reactivity :
Human, Mouse, Rat
sequence length :
1141
purity :
>85%
form :
Lyophilized powder
storage stability :
Ships on blue ice. Store at -20 degree C for one year.
tested application :
Blocking (BL)
app notes :
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
other info1 :
Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
products description :
The peptide is used to block Anti-Integrin alpha 7 LC Antibody reactivity.
ncbi gi num :
222418613
ncbi acc num :
NP_001138468.1
ncbi gb acc num :
NM_001144996.1
uniprot acc num :
P07766
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795)
ncbi summary :
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
uniprot summary :
ITGA7: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Defects in ITGA7 are the cause of muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI). A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. Belongs to the integrin alpha chain family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: muscle tendon junction; cell surface; cytoplasm; plasma membrane; neuromuscular junction; sarcolemma. Molecular Function: integrin binding; protein heterodimerization activity; metal ion binding; laminin binding. Biological Process: integrin-mediated signaling pathway; regulation of cell shape; heterotypic cell-cell adhesion; cell migration; extracellular matrix organization and biogenesis; skeletal muscle development; muscle development; cell-matrix adhesion; blood vessel morphogenesis. Disease: Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency
size1 :
1 mg
price1 :
160 USD
size2 :
5 mg
price2 :
305
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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