protein

DnaJC3 Blocking Peptide

MBS8231349

1 mg

160 USD

Blocking Peptide

DnaJC3 Blocking Peptide

[DnaJC3]

[P58IPK; PRKRI; DnaJ homolog subfamily C member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58]

[dnaJ homolog subfamily C member 3; DnaJ homolog subfamily C member 3; dnaJ homolog subfamily C member 3; DnaJ (Hsp40) homolog, subfamily C, member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58]

[DNAJC3]

[DNAJC3; DNAJC3; P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK; P58IPK; PRKRI; ER-resident protein ERdj6; ERdj6; Protein kinase inhibitor p58]

DNJC3_HUMAN

Human, Mouse, Rat, Bovine, Porcine

504

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Blocking (BL)

Source: Synthetic

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

The peptide is used to block Anti-DnaJC3 Antibody reactivity.

5453980

NP_006251.1

NM_006260.4

Q13217

Disease Pathway (1268854); IRE1alpha Activates Chaperones Pathway (1268759); Infectious Disease Pathway (1269056); Influenza A Pathway (217173); Influenza A Pathway (217150); Influenza Infection Pathway (1269108); Influenza Life Cycle Pathway (1269109); Influenza Viral RNA Transcription And Replication Pathway (1269115); Metabolism Of Proteins Pathway (1268677); Protein Processing In Endoplasmic Reticulum Pathway (167325)

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Protein type: Endoplasmic reticulum; Inhibitor; Protein kinase, regulatory subunit; Chaperone. Chromosomal Location of Human Ortholog: 13q32.1. Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle. Molecular Function: protein kinase inhibitor activity; chaperone binding; misfolded protein binding. Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; proteolysis involved in cellular protein catabolic process; unfolded protein response; negative regulation of protein kinase activity; defense response to virus; negative regulation of apoptosis. Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus

1 mg

160 USD

5 mg

305