protein

TFEB Blocking Peptide

MBS823070

1 mg

160 USD

Blocking Peptide

TFEB Blocking Peptide

[TFEB]

[BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35]

[transcription factor EB isoform 2; Transcription factor EB; transcription factor EB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35]

[TFEB]

[TFEB; TFEB; TCFEB; BHLHE35; ALPHATFEB; BHLHE35; bHLHe35]

TFEB_HUMAN

Synthetic

Human, Mouse, Rat, Bovine, Dog, Pig

490

>85%

Lyophilized powder

Shipping: Blue Ice. Store at -20°C for one year.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

The peptide is used to block Anti-TFEB Antibody reactivity.

429836865

NP_001161299.2

NM_001167827.2

P19484

TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3 -CANNTG-5 ). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5 -GTCACGTGAC-3 ) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein dimerization activity; transcription factor activity. Biological Process: embryonic placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; humoral immune response

1 mg

160 USD

5 mg

305