Anti-Aquaporin 3 Antibody | MyBioSource MBS8230669 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Aquaporin 3 Antibody

catalog :

MBS8230669

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, zebrafish

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Aquaporin 3 expression in LOVO (A), A431 (B), NIH3T3 (C), rat kidney (D) whole cell lysates.

image 2 :

Immunohistochemical analysis of Aquaporin 3 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8230669

products type :

Antibody

products full name :

Anti-Aquaporin 3 Antibody

products short name :

[Aquaporin 3]

products name syn :

[Aquaporin-3; AQP-3; Aquaglyceroporin-3]

other names :

[aquaporin-3; Aquaporin-3; aquaporin-3; aquaporin 3 (Gill blood group); Aquaglyceroporin-3]

products gene name :

[AQP3]

other gene names :

[AQP3; AQP3; GIL; AQP-3; AQP-3]

uniprot entry name :

AQP3_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Bovine, Monkey, Porcine, Sheep, Zebrafish

sequence length :

292

specificity :

Recognizes endogenous levels of Aquaporin 3 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB (1/500 - 1/1000), IHC (1/100 - 1/200)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Aquaporin 3. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Aquaporin 3

ncbi gi num :

4826645

ncbi acc num :

NP_004916.1

ncbi gb acc num :

NM_004925.4

uniprot acc num :

Q92482

ncbi pathways :

Aquaporin-mediated Transport Pathway (1269944); Passive Transport By Aquaporins Pathway (1269945); Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway (137918); Transmembrane Transport Of Small Molecules Pathway (1269903); Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway (1269946); Vasopressin-regulated Water Reabsorption Pathway (143700); Vasopressin-regulated Water Reabsorption Pathway (143631)

ncbi summary :

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

uniprot summary :

AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter; Transporter, aquaporin family. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; intercellular junction. Molecular Function: transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity. Biological Process: positive regulation of immune system process; glycerol transport; response to retinoic acid; cellular water homeostasis; water transport; excretion; odontogenesis; response to vitamin D; transport; renal water homeostasis; response to calcium ion; regulation of keratinocyte differentiation; transmembrane transport. Disease: Gil Blood Group

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage