CD91 Blocking Peptide | MyBioSource MBS822820 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

CD91 Blocking Peptide

catalog :

MBS822820

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS822820

products type :

Blocking Peptide

products full name :

CD91 Blocking Peptide

products short name :

[CD91]

products name syn :

[A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD91]

other names :

[prolow-density lipoprotein receptor-related protein 1; Prolow-density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor; low density lipoprotein receptor-related protein 1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD_antigen: CD91Cleaved into the following 3 chains:Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD]

products gene name :

[LRP1]

other gene names :

[LRP1; LRP1; APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD]

uniprot entry name :

LRP1_HUMAN

host :

Synthetic

reactivity :

Human, Mouse, Rat, Pig

sequence length :

4544

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipping: Blue ice. Store at -20°C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

other info1 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

products description :

The peptide is used to block Anti-CD91 Antibody reactivity.

ncbi gi num :

126012562

ncbi acc num :

NP_002323.2

ncbi gb acc num :

NM_002332.2

uniprot acc num :

Q07954

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Malaria Pathway (152665); Malaria Pathway (152657); PDGFR-beta Signaling Pathway (138071); Retinoid Metabolism And Transport Pathway (187208)

ncbi summary :

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

uniprot summary :

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung. Protein type: Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: focal adhesion; clathrin-coated vesicle; cell soma; integral to plasma membrane; lysosomal membrane; cytoplasm; dendrite; plasma membrane; nucleolus; coated pit; receptor complex; endosome. Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; receptor activity; calcium ion binding. Biological Process: phototransduction, visible light; receptor-mediated endocytosis; cholesterol metabolic process; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; cell proliferation; positive regulation of lipid transport; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage