GHRH Receptor Blocking Peptide | MyBioSource MBS822773 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

GHRH Receptor Blocking Peptide

catalog :

MBS822773

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS822773

products type :

Blocking Peptide

products full name :

GHRH Receptor Blocking Peptide

products short name :

[GHRH]

products name syn :

[Growth hormone-releasing hormone receptor; GHRH receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR]

other names :

[growth hormone-releasing hormone receptor; Growth hormone-releasing hormone receptor; growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor; growth hormone releasing hormone receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR]

products gene name :

[GHRHR]

other gene names :

[GHRHR; GHRHR; GRFR; GHRFR; IGHD1B; GHRH receptor; GRF receptor; GRFR]

uniprot entry name :

GHRHR_HUMAN

reactivity :

Human, Mouse, Rat, Monkey

sequence length :

423

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipped at 4°C. Store at -20°C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

other info1 :

Source: Synthetic. Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

products description :

The peptide is used to block Anti-GHRH Receptor Antibody reactivity.

ncbi gi num :

58530851

ncbi acc num :

NP_000814.2

ncbi gb acc num :

NM_000823.3

uniprot acc num :

Q02643

ncbi mol weight :

47,402 Da

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class B Secretin-like Pathway (198781); GPCRs, Other Pathway (198765); Glucagon-type Ligand Receptors Pathway (106380); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Signal Transduction Pathway (477114)

ncbi summary :

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

uniprot summary :

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family. Protein type: Membrane protein, multi-pass; Cell development/differentiation; Receptor, GPCR; GPCR, family 2; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7p14. Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule. Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity. Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; lactation; adenylate cyclase activation; cell maturation; response to glucocorticoid stimulus; regulation of protein metabolic process; determination of adult life span; positive regulation of multicellular organism growth; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; water homeostasis; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; somatotropin secreting cell development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; hormone metabolic process; regulation of steroid hormone receptor signaling pathway. Disease: Isolated Growth Hormone Deficiency, Type Ib

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage