EPHB3 Blocking Peptide | MyBioSource MBS822644 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

EPHB3 Blocking Peptide

catalog :

MBS822644

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS822644

products type :

Blocking Peptide

products full name :

EPHB3 Blocking Peptide

products short name :

[EPHB3]

products name syn :

[ETK2; HEK2; TYRO6; Ephrin type-B receptor 3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; Tyrosine-protein kinase TYRO6]

other names :

[ephrin type-B receptor 3; Ephrin type-B receptor 3; ephrin type-B receptor 3; EK2; EPH-like kinase 2; embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; tyrosine-protein kinase TYRO6; EPH receptor B3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; Tyrosine-protein kinase TYRO6]

products gene name :

[EPHB3]

other gene names :

[EPHB3; EPHB3; ETK2; HEK2; TYRO6; ETK2; HEK2; TYRO6; EPH-like kinase 2; EK2; hEK2]

uniprot entry name :

EPHB3_HUMAN

host :

Synthetic

reactivity :

Human, Mouse, Rat, Chicken, Pig

sequence length :

998

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipping: Blue ice. Store at -20°C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

other info1 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

products description :

The peptide is used to block Anti-EPHB3 Antibody reactivity.

ncbi gi num :

17975768

ncbi acc num :

NP_004434.2

ncbi gb acc num :

NM_004443.3

uniprot acc num :

P54753

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174); EPH-ephrin Mediated Repulsion Of Cells Pathway (1016178); EPHB Forward Signaling Pathway (138047); EPHB-mediated Forward Signaling Pathway (1016176); Ephrin Signaling Pathway (1016177); EphrinB-EPHB Pathway (137951)

ncbi summary :

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

uniprot summary :

EphB3: a ubiquitous receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members: ephrin-B1 and -B2. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.EphB3 contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains. Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Eph family. Chromosomal Location of Human Ortholog: 3q27.1. Cellular Component: integral to plasma membrane; dendrite; plasma membrane; extracellular region; cytosol. Molecular Function: ephrin receptor activity; axon guidance receptor activity; ATP binding. Biological Process: axon guidance; cell migration; peptidyl-tyrosine phosphorylation; thymus development; protein amino acid autophosphorylation; axonal fasciculation; central nervous system projection neuron axonogenesis; digestive tract morphogenesis; palate development; regulation of axonogenesis; corpus callosum development; positive regulation of synaptogenesis; regulation of cell-cell adhesion; ephrin receptor signaling pathway; angiogenesis; urogenital system development; retinal ganglion cell axon guidance

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage