IFNGR1 (pY457) Blocking Peptide | MyBioSource MBS822430 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

IFNGR1 (pY457) Blocking Peptide

catalog :

MBS822430

quantity :

1 mg

price :

195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS822430

products type :

Blocking Peptide

products full name :

IFNGR1 (pY457) Blocking Peptide

products short name :

[IFNGR1 (pY457)]

products name syn :

[Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119]

other names :

[interferon gamma receptor 1; Interferon gamma receptor 1; interferon gamma receptor 1; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain; interferon gamma receptor 1; CDw119; CD_antigen: CD119]

products gene name :

[IFNGR1]

other gene names :

[IFNGR1; IFNGR1; CD119; IFNGR; IMD27A; IMD27B; IFN-gamma receptor 1; IFN-gamma-R1]

uniprot entry name :

INGR1_HUMAN

host :

Synthetic

reactivity :

Human, Mouse, Rat, Monkey

sequence length :

489

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipping: Blue ice. Store at -20°C for one year.

tested application :

Blocking (BL)

app notes :

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4°C for overnight or at room temperature for 2 hours.

other info1 :

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

products description :

The peptide is used to block Anti-IFNGR1 (pY457) Antibody reactivity.

ncbi gi num :

4557880

ncbi acc num :

NP_000407.1

ncbi gb acc num :

NM_000416.2

uniprot acc num :

P15260

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HIF-1 Signaling Pathway (695200); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); IFN-gamma Pathway (138040); Immune System Pathway (106386)

ncbi summary :

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

uniprot summary :

IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6q23.3. Cellular Component: integral to plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; integral to membrane; plasma membrane; vesicle. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; interferon-gamma receptor activity; cytokine binding. Biological Process: response to virus; cytokine and chemokine mediated signaling pathway; signal transduction. Disease: Helicobacter Pylori Infection, Susceptibility To; Immunodeficiency 27b; Immunodeficiency 27a; Mycobacterium Tuberculosis, Susceptibility To; Hepatitis B Virus, Susceptibility To

size1 :

1 mg

price1 :

195 USD

size2 :

5 mg

price2 :

435

more info or order :

MyBioSource product webpage