SERCA1 Blocking Peptide | MyBioSource MBS822370 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

SERCA1 Blocking Peptide

catalog :

MBS822370

quantity :

1 mg

price :

160 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS822370

products type :

Blocking Peptide

products full name :

SERCA1 Blocking Peptide

products short name :

[SERCA1]

products name syn :

[Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase]

other names :

[sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform c; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase]

products gene name :

[ATP2A1]

other gene names :

[ATP2A1; ATP2A1; ATP2A; SERCA1; SERCA1; SR Ca(2+)-ATPase 1]

uniprot entry name :

AT2A1_HUMAN

host :

Synthetic

reactivity :

Human, Mouse, Rat, Bovine, Rabbit

sequence length :

869

purity :

>85%

form :

Lyophilized powder

storage stability :

Shipped at 4 degree C. Store at -20 degree C for one year.

tested application :

Blocking

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemical

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SERCA1. The exact sequence is proprietary.

other info2 :

Entrez Gene: 487 (Human); 11937 (Mouse); 116601 (Rat). Swiss Prot: O14983 (Human); Q8R429 (Mouse); Q64578 (Rat). Quality Control: The quality of the peptide was evaluated by reversed - phase HPLC and by mass spectrometry. Directions for Use: Blocking Peptide to the dil uted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

products description :

The peptide is used to block Anti - SERCA1 Antibody reactivity.

ncbi gi num :

554506571

ncbi acc num :

NP_001273004.1

ncbi gb acc num :

NM_001286075.1

uniprot acc num :

O14983

ncbi mol weight :

95,199 Da

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Hemostasis Pathway (106028); Ion Channel Transport Pathway (187193); Ion Transport By P-type ATPases Pathway (187194); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295)

ncbi summary :

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

uniprot summary :

ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.6.3.8; Transporter, ion channel; Endoplasmic reticulum; Hydrolase; Membrane protein, multi-pass; Transporter; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p12.1. Cellular Component: I band; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; ER-Golgi intermediate compartment. Molecular Function: protein binding; protein homodimerization activity; calcium-transporting ATPase activity; calcium ion binding; ATP binding. Biological Process: apoptotic mitochondrial changes; positive regulation of fast-twitch skeletal muscle contraction; maintenance of mitochondrion localization; metabolic process; reduction of endoplasmic reticulum calcium ion concentration; elevation of endoplasmic reticulum calcium ion concentration; calcium ion transport; regulation of striated muscle contraction; blood coagulation; transmembrane transport; elevation of mitochondrial calcium ion concentration; negative regulation of striated muscle contraction. Disease: Brody Myopathy

size1 :

1 mg

price1 :

160 USD

size2 :

5 mg

price2 :

305

more info or order :

MyBioSource product webpage