Anti-CD184 (pS339) Antibody | MyBioSource MBS822232 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD184 (pS339) Antibody

catalog :

MBS822232

quantity :

0.03 mL

price :

165 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of CD184 (pS339) expression in HEK293T colchicine-treated (A), HL60 (B), Jurkat (C), mouse spleen (D), rat spleen (E) whole cell lysates.

product information

catalog number :

MBS822232

products type :

Antibody

products full name :

Anti-CD184 (pS339) Antibody

products short name :

[CD184 (pS339)]

products name syn :

[C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD184]

other names :

[C-X-C chemokine receptor type 4 isoform a; C-X-C chemokine receptor type 4; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; chemokine (C-X-C motif) receptor 4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184]

products gene name :

[CXCR4]

other gene names :

[CXCR4; CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor]

uniprot entry name :

CXCR4_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Bovine, Dog, Monkey, Pig

sequence length :

356

specificity :

Recognizes endogenous levels of CD184 (pS339) protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Soure: Rabbit

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD184. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to CD184 (pS339)

ncbi gi num :

56790927

ncbi acc num :

NP_001008540.1

ncbi gb acc num :

NM_001008540.1

uniprot acc num :

P61073

ncbi mol weight :

40,221 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Binding And Entry Of HIV Virion Pathway (105986); CXCR4-mediated Signaling Events Pathway (137910); Cardiac Progenitor Differentiation Pathway (712094); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051)

ncbi summary :

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 2q21. Cellular Component: growth cone; cell surface; lysosome; cytoplasm; leading edge; cytoplasmic membrane-bound vesicle; early endosome; late endosome; plasma membrane; integral to membrane; cytoplasmic vesicle; intercellular junction; external side of plasma membrane. Molecular Function: G-protein coupled receptor activity; viral receptor activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; cytokine binding; myosin light chain binding; coreceptor activity; actin binding; C-X-C chemokine receptor activity. Biological Process: entry of virus into host cell; regulation of chemotaxis; viral reproduction; neutrophil activation; activation of MAPK activity; apoptosis; response to virus; neuron migration; calcium-mediated signaling; motor axon guidance; regulation of cell migration; germ cell development; T cell proliferation; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; ameboidal cell migration; germ cell migration; myelin maintenance; response to hypoxia; dendritic cell chemotaxis; entry into host cell; brain development; positive regulation of oligodendrocyte differentiation; inflammatory response. Disease: Whim Syndrome

size1 :

0.03 mL

price1 :

165 USD

size2 :

0.1 mL

price2 :

245

size3 :

0.2 mL

price3 :

350

more info or order :

MyBioSource product webpage