Anti-IRAK1 (pT209) Antibody | MyBioSource MBS822180 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-IRAK1 (pT209) Antibody

catalog :

MBS822180

quantity :

0.03 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of IRAK1 (pT209) expression in MCF7 IL1b-treated (A), K562 (B), MCF7 (C), Raw264.7 IL1b-treated (D) whole cell lysates.

product information

catalog number :

MBS822180

products type :

Antibody

products full name :

Anti-IRAK1 (pT209) Antibody

products short name :

[IRAK1 (pT209)]

products name syn :

[IRAK; Interleukin-1 receptor-associated kinase 1; IRAK-1]

other names :

[interleukin-1 receptor-associated kinase 1 isoform 2; Interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase 1; IRAK-1; Pelle homolog; interleukin-1 receptor-associated kinase 1]

products gene name :

[IRAK1]

other gene names :

[IRAK1; IRAK1; IRAK; pelle; IRAK; IRAK-1]

uniprot entry name :

IRAK1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

682

specificity :

Recognizes endogenous levels of IRAK1 (pT209) protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IRAK1. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to IRAK1 (pT209)

ncbi gi num :

68800343

ncbi acc num :

NP_001020413.1

ncbi gb acc num :

NM_001025242.1

uniprot acc num :

P51617

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Modulation And Signaling Pathway (198822); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (366171); EBV LMP1 Signaling Pathway (198790); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115)

ncbi summary :

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

IRAK1: a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through Lys-63 . Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; IRAK family. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: interleukin-1 receptor complex; cytoplasm; plasma membrane; lipid particle; endosome membrane; cytosol; nucleus. Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; protein homodimerization activity; protein heterodimerization activity; heat shock protein binding; ubiquitin-protein ligase activity; kinase activity; ATP binding; protein kinase activity. Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; stress-activated MAPK cascade; protein ubiquitination; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; positive regulation of MAP kinase activity; response to peptidoglycan; transmembrane receptor protein serine/threonine kinase signaling pathway; lipopolysaccharide-mediated signaling pathway; JNK cascade; toll-like receptor 4 signaling pathway; aging; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; protein oligomerization; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; toll-like receptor signaling pathway; regulation of cytokine and chemokine mediated signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; negative regulation of apoptosis

size1 :

0.03 mL

price1 :

165 USD

size2 :

0.1 mL

price2 :

245

size3 :

0.2 mL

price3 :

350

more info or order :

MyBioSource product webpage