Anti-STAT1 Antibody | MyBioSource MBS8219182 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-STAT1 Antibody

catalog :

MBS8219182

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of STAT1 expression in HeLa (A), NIH3T3 (B), PC12 (C) whole cell lysates.

image 2 :

Immunohistochemical analysis of STAT1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8219182

products type :

Antibody

products full name :

Anti-STAT1 Antibody

products short name :

[STAT1]

products name syn :

[Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84]

other names :

[signal transducer and activator of transcription 1-alpha/beta isoform alpha; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1, 91kDa; Transcription factor ISGF-3 components p91/p84]

products gene name :

[STAT1]

other gene names :

[STAT1; STAT1; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91]

uniprot entry name :

STAT1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Porcine

sequence length :

750

specificity :

Recognizes endogenous levels of STAT1 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

app notes :

WB (1/500 - 1/1000), IHC (1/100 - 1/200), IP (1/10 - 1/100)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human STAT1. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to STAT1

ncbi gi num :

6274552

ncbi acc num :

NP_009330.1

ncbi gb acc num :

NM_007315.3

uniprot acc num :

P42224

ncbi mol weight :

83,043 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Adipogenesis Pathway (198832); Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Cytokine Signaling In Immune System Pathway (1269310); Disease Pathway (1268854)

ncbi summary :

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: nucleoplasm; axon; dendrite; cytoplasm; nuclear chromatin; nucleolus; nucleus; cytosol. Molecular Function: identical protein binding; signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; double-stranded DNA binding; tumor necrosis factor receptor binding; transcription factor activity; CCR5 chemokine receptor binding. Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; cellular response to insulin stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter. Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage