Anti-Cytochrome P450 2D6 Antibody | MyBioSource MBS821765 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Cytochrome P450 2D6 Antibody

catalog :

MBS821765

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Cytochrome P450 2D6 expression in A431 (A), K562 (B), HuvEc (C) whole cell lysates.

product information

catalog number :

MBS821765

products type :

Antibody

products full name :

Anti-Cytochrome P450 2D6 Antibody

products short name :

[Cytochrome P450 2D6]

products name syn :

[CYP2DL1; Cytochrome P450 2D6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase]

other names :

[cytochrome P450 2D6 isoform 1; Cytochrome P450 2D6; cytochrome P450 2D6; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase]

products gene name :

[CYP2D6]

other gene names :

[CYP2D6; CYP2D6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; CYP2DL1]

uniprot entry name :

CP2D6_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Monkey

sequence length :

497

specificity :

Recognizes endogenous levels of Cytochrome P450 2D6 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunoprecipitation (IP)

app notes :

WB (1/500 - 1/1000), IP (1/10 - 1/100)

image1 heading :

Western Blot (WB)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 2D6. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Cytochrome P450 2D6

ncbi gi num :

392513721

ncbi acc num :

NP_000097.3

ncbi gb acc num :

NM_000106.5

uniprot acc num :

P10635

ncbi pathways :

Biological Oxidations Pathway (105698); CYP2E1 Reactions Pathway (105705); Codeine And Morphine Metabolism Pathway (198831); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Fatty Acid Omega Oxidation Pathway (198915); Fatty Acids Pathway (105706); Metabolism Pathway (477135); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

uniprot summary :

CYP2D6: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Belongs to the cytochrome P450 family. Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; EC 1.14.14.1. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum. Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; oxidoreductase activity; drug binding; steroid hydroxylase activity; oxygen binding; monooxygenase activity. Biological Process: steroid metabolic process; coumarin metabolic process; monoterpenoid metabolic process; isoquinoline alkaloid metabolic process; negative regulation of binding; drug catabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process; alkaloid catabolic process; alkaloid metabolic process; heterocycle metabolic process; drug metabolic process. Disease: Drug Metabolism, Poor, Cyp2d6-related

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage