catalog number :
MBS8216211
products full name :
Anti-Apolipoprotein C1 Antibody
products short name :
[Apolipoprotein C1]
products name syn :
[Apolipoprotein C-I; Apolipoprotein C1]
other names :
[apolipoprotein C-I; Apolipoprotein C-I; apolipoprotein C-I; apolipoprotein C-I; Apolipoprotein C1]
products gene name :
[APOC1]
other gene names :
[APOC1; APOC1; Apo-CI; ApoC-I; Apo-CI; ApoC-I]
uniprot entry name :
APOC1_HUMAN
reactivity :
Human, Mouse
specificity :
Recognizes endogenous levels of Apolipoprotein C1 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Apolipoprotein C1. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to Apolipoprotein C1
ncbi acc num :
NP_001636.1
ncbi gb acc num :
NM_001645.3
ncbi mol weight :
9,332 Da
ncbi pathways :
Statin Pathway (198852)
ncbi summary :
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family. Protein type: Inhibitor; Lipid-binding; Secreted, signal peptide; Secreted; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: chylomicron; endoplasmic reticulum. Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding. Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; triacylglycerol metabolic process; negative regulation of lipid catabolic process; phospholipid efflux; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process