Anti-Neuropilin 1 Antibody | MyBioSource MBS821583 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Neuropilin 1 Antibody

catalog :

MBS821583

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Neuropilin 1 expression in HUVEC (A), MDAMB231 (B), COS7 (C) whole cell lysates.

image 2 :

product information

catalog number :

MBS821583

products type :

Antibody

products full name :

Anti-Neuropilin 1 Antibody

products short name :

[Neuropilin 1]

products name syn :

[NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304]

other names :

[neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; neuropilin 1; Vascular endothelial cell growth factor 165 receptor; CD_antigen: CD304]

products gene name :

[NRP1]

other gene names :

[NRP1; NRP1; NP1; NRP; BDCA4; CD304; VEGF165R; NRP; VEGF165R]

uniprot entry name :

NRP1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Rat, Monkey

sequence length :

644

specificity :

Recognizes endogenous levels of Neuropilin 1 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4°C. Upon delivery aliquot and store at -20° C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Neuropilin 1. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Neuropilin 1

ncbi gi num :

66912178

ncbi acc num :

NP_001019799.1

ncbi gb acc num :

NM_001024628.2

uniprot acc num :

O14786

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509)

ncbi summary :

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 10p12. Cellular Component: extracellular space; cell surface; focal adhesion; early endosome; integral to membrane; cytosol; growth cone; cell soma; axon; plasma membrane; neurofilament; cytoplasmic vesicle; receptor complex. Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; growth factor binding; cytokine binding; metal ion binding; coreceptor activity. Biological Process: facial nerve structural organization; axon guidance; neuron migration; vestibulocochlear nerve structural organization; platelet-derived growth factor receptor signaling pathway; signal transduction; negative regulation of axon extension involved in axon guidance; positive regulation of smooth muscle cell migration; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; cell-cell signaling; positive chemotaxis; branchiomotor neuron axon guidance; dendrite development; response to wounding; negative regulation of neuron apoptosis; angiogenesis; trigeminal nerve structural organization; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; patterning of blood vessels; axon extension involved in axon guidance; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; otic placode formation; positive regulation of axon extension involved in axon guidance; artery morphogenesis; nerve development; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; retinal ganglion cell axon guidance

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage