Anti-p22 phox Antibody | MyBioSource MBS821526 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-p22 phox Antibody

catalog :

MBS821526

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of p22 phox expression in MCF7 (A), NIH3T3 (B), PC12 (C) whole cell lysates.

product information

catalog number :

MBS821526

products type :

Antibody

products full name :

Anti-p22 phox Antibody

products short name :

[p22 phox]

products name syn :

[Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox]

other names :

[cytochrome b-245 light chain; Cytochrome b-245 light chain; cytochrome b-245 light chain; p22phox; cytochrome b light chain; p22 phagocyte B-cytochrome; cytochrome b(558) alpha chain; cytochrome b558 subunit alpha; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; flavocytochrome b-558 alpha polypeptide; neutrophil cytochrome b 22 kDa polypeptide; superoxide-generating NADPH oxidase light chain subunit; cytochrome b-245, alpha polypeptide; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox]

products gene name :

[CYBA]

other gene names :

[CYBA; CYBA; p22-PHOX; p22phox]

uniprot entry name :

CY24A_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Pig

sequence length :

195

specificity :

Recognizes endogenous levels of p22 phox protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Source: Rabbit

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p22 phox. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to p22 phox

ncbi gi num :

68509914

ncbi acc num :

NP_000092.2

ncbi gb acc num :

NM_000101.3

uniprot acc num :

P13498

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway (477123); Disease Pathway (530764); Immune System Pathway (106386); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Leishmaniasis Pathway (144181); Leishmaniasis Pathway (144028); Leukocyte Transendothelial Migration Pathway (83083)

ncbi summary :

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

uniprot summary :

CYBA: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family. Protein type: Oxidoreductase; EC 1.-.-.-; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16q24. Cellular Component: Golgi apparatus; phagocytic vesicle membrane; cell soma; mitochondrion; membrane; apical plasma membrane; dendrite; plasma membrane; endosome; NADPH oxidase complex; secretory granule. Molecular Function: protein binding; electron carrier activity; protein heterodimerization activity; superoxide-generating NADPH oxidase activity; metal ion binding; heme binding; SH3 domain binding. Biological Process: respiratory burst; response to drug; response to nutrient levels; interaction with host; angiotensin-mediated regulation of glomerular filtration; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; regulation of release of sequestered calcium ion into cytosol; antigen processing and presentation of peptide antigen via MHC class I; cytochrome complex assembly; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of endothelial cell proliferation; smooth muscle hypertrophy; vascular endothelial growth factor receptor signaling pathway; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process. Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage