Anti-Inhibin beta A Antibody | MyBioSource MBS821350 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Inhibin beta A Antibody

catalog :

MBS821350

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Inhibin beta A expression in HeLa (A), HepG2 (B), mouse brain (C), H9C2 (D) whole cell lysates.

product information

catalog number :

MBS821350

products type :

Antibody

products full name :

Anti-Inhibin beta A Antibody

products short name :

[Inhibin beta A]

products name syn :

[Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein; EDF]

other names :

[inhibin beta A chain; Inhibin beta A chain; inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin, beta A; Activin beta-A chain; Erythroid differentiation protein; EDF]

products gene name :

[INHBA]

other gene names :

[INHBA; INHBA; EDF; FRP; EDF]

uniprot entry name :

INHBA_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Sheep

sequence length :

426

specificity :

Recognizes endogenous levels of Inhibin beta A protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipping: Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Inhibin beta A. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Inhibin beta A

ncbi gi num :

4504699

ncbi acc num :

NP_002183.1

ncbi gb acc num :

NM_002192.2

uniprot acc num :

P08476

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Antagonism Of Activin By Follistatin Pathway (730350); Cardiac Progenitor Differentiation Pathway (712094); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Glycoprotein Hormones Pathway (160989); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Peptide Hormone Biosynthesis Pathway (160988); Peptide Hormone Metabolism Pathway (771603)

ncbi summary :

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

uniprot summary :

INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7p15-p13. Cellular Component: extracellular region. Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; peptide hormone binding; hormone activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; activin receptor signaling pathway; mesodermal cell differentiation; defense response; palate development; negative regulation of interferon-gamma biosynthetic process; negative regulation of cell cycle; odontogenesis; negative regulation of cell proliferation; cell surface receptor linked signal transduction; hair follicle development; ovarian follicle development; cell-cell signaling; erythrocyte differentiation; cell differentiation; cell cycle arrest; response to drug; hemoglobin biosynthetic process; negative regulation of B cell differentiation; nervous system development; regulation of follicle-stimulating hormone secretion; positive regulation of erythrocyte differentiation; male gonad development; progesterone secretion; negative regulation of follicle-stimulating hormone secretion; regulation of transcription from RNA polymerase II promoter; negative regulation of macrophage differentiation; regulation of MAPKKK cascade; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; positive regulation of follicle-stimulating hormone secretion; negative regulation of cell growth; cell development; growth; G1/S transition of mitotic cell cycle

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage