product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-MT-ND2 Antibody
catalog :
MBS821343
quantity :
0.03 mL
price :
155 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of MT-ND2 expression in HepG2 (A), Raw264.7 (B), PC12 (C) whole cell lysates.
product information
catalog number :
MBS821343
products type :
Antibody
products full name :
Anti-MT-ND2 Antibody
products short name :
[MT-ND2]
products name syn :
[MTND2; NADH2; ND2; NADH-ubiquinone oxidoreductase chain 2; NADH dehydrogenase subunit 2]
other names :
[NADH dehydrogenase subunit 2 (mitochondrion); NADH-ubiquinone oxidoreductase chain 2; MTND2; NADH dehydrogenase subunit 2; mitochondrially encoded NADH dehydrogenase 2; NADH dehydrogenase subunit 2]
products gene name :
[MT-ND2]
other gene names :
[MT-ND2; MT-ND2; MTND2; ND2; MTND2; NADH2; ND2]
uniprot entry name :
NU2M_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
347
specificity :
Recognizes endogenous levels of MT-ND2 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MT-ND2. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to MT-ND2
ncbi gi num :
251831108
ncbi acc num :
YP_003024027.1
ncbi gb acc num :
NC_012920.1
uniprot acc num :
P03891
ncbi pathways :
Electron Transport Chain Pathway (198860); Metabolic Pathways (132956); Metabolism Pathway (477135); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (413406); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (890440); Oxidative Phosphorylation Pathway (198870); Oxidative Phosphorylation Pathway (82942); Oxidative Phosphorylation Pathway (303); Parkinson's Disease Pathway (83098); Respiratory Electron Transport Pathway (160962)
uniprot summary :
MT-ND2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT). Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Belongs to the complex I subunit 2 family. Protein type: EC 1.6.5.3; Oxidoreductase; Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation. Chromosomal Location of Human Ortholog: -. Disease: Leber Optic Atrophy
size1 :
0.03 mL
price1 :
155 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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