Anti-PKC delta (pY52) Antibody | MyBioSource MBS821123 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-PKC delta (pY52) Antibody

catalog :

MBS821123

quantity :

0.03 mL

price :

165 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of PKC delta (pY52) expression in MCF7 serum starvation-treated (A), HeLa PMA-treated (B), Jurkat (C), Raw264.7 serum starvation-treated (D), H9C2 serum starvation-treated (E) whole cell lysates.

product information

catalog number :

MBS821123

products type :

Antibody

products full name :

Anti-PKC delta (pY52) Antibody

products short name :

[PKC delta (pY52)]

products name syn :

[Protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta]

other names :

[protein kinase C delta type; Protein kinase C delta type; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; protein kinase C, delta; Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-deltaCleaved into the following 2 chains:Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunitAlternative name(s):Sphingosine-dependent protein kinase-1; SDK1]

products gene name :

[PRKCD]

other gene names :

[PRKCD; PRKCD; MAY1; PKCD; ALPS3; CVID9; nPKC-delta; SDK1]

uniprot entry name :

KPCD_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit

sequence length :

676

specificity :

Recognizes endogenous levels of PKC delta (pY52) protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info1 :

Source: Rabbit

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PKC delta. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to PKC delta (pY52)

ncbi gi num :

31377782

ncbi acc num :

NP_006245.2

ncbi gb acc num :

NM_006254.3

uniprot acc num :

Q05655

ncbi pathways :

AGE/RAGE Pathway (698754); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); Ca-dependent Events Pathway (106497); CaM Pathway (106468)

ncbi summary :

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

uniprot summary :

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Protein type: Protein kinase, AGC; EC 2.7.11.13; Nuclear receptor co-regulator; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKC family; Delta subfamily. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus. Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; enzyme binding; protein kinase C activity; insulin receptor substrate binding; metal ion binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding. Biological Process: B cell proliferation; negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; interleukin-12 production; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; protein stabilization; neutrophil activation; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; induction of apoptosis by oxidative stress. Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii

size1 :

0.03 mL

price1 :

165 USD

size2 :

0.1 mL

price2 :

245

size3 :

0.2 mL

price3 :

350

more info or order :

MyBioSource product webpage