product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
Anti-OPA1 Antibody
catalog :
MBS8210195
quantity :
0.03 mL
price :
155 USD
clonality :
polyclonal
host :
unidentified
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of OPA1 expression in A549 (A), Raw264.7 (B), PC12 (C) whole cell lysates.
product information
catalog number :
MBS8210195
products type :
Antibody
products full name :
Anti-OPA1 Antibody
products short name :
[OPA1]
products name syn :
[KIAA0567; Dynamin-like 120 kDa protein, mitochondrial; Optic atrophy protein 1]
other names :
[dynamin-like 120 kDa protein, mitochondrial isoform 1; Dynamin-like 120 kDa protein, mitochondrial; dynamin-like 120 kDa protein, mitochondrial; optic atrophy 1 (autosomal dominant); Optic atrophy protein 1]
products gene name :
[OPA1]
other gene names :
[OPA1; OPA1; NPG; NTG; MGM1; largeG; KIAA0567]
uniprot entry name :
OPA1_HUMAN
clonality :
Polyclonal
host :
unknown
reactivity :
Human, Mouse, Rat
sequence length :
960
specificity :
Recognizes endogenous levels of OPA1 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human OPA1. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to OPA1
ncbi gi num :
224831243
ncbi acc num :
NP_056375.2
ncbi gb acc num :
NM_015560.2
uniprot acc num :
O60313
ncbi summary :
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
uniprot summary :
OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described. Protein type: Hydrolase; Mitochondrial; EC 3.6.5.5; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; dendrite; cytoplasm; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space. Molecular Function: GTPase activity; protein binding; GTP binding; magnesium ion binding. Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrion organization and biogenesis; mitochondrial fission; mitochondrial genome maintenance; axon transport of mitochondrion; visual perception; mitochondrial fusion; apoptosis; metabolic process; neural tube closure. Disease: Glaucoma, Normal Tension, Susceptibility To; Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy; Optic Atrophy 1
size1 :
0.03 mL
price1 :
155 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
related products
browse more products
questions and comments