PTPRS siRNA (Human) | MyBioSource MBS8209636 product information

product summary

company name :

MyBioSource

product type :

gene knockdown

product name :

PTPRS siRNA (Human)

catalog :

MBS8209636

quantity :

15 nmol

price :

365 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8209636

products type :

siRNA

products full name :

PTPRS siRNA (Human)

products short name :

[PTPRS]

products name syn :

[Receptor-type tyrosine-protein phosphatase S; R-PTP-S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma]

other names :

[receptor-type tyrosine-protein phosphatase S isoform 1; Receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase S; protein tyrosine phosphatase, receptor type, S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma]

products gene name :

[PTPRS]

other gene names :

[PTPRS; PTPRS; PTPSIGMA; R-PTP-S; R-PTP-sigma]

uniprot entry name :

PTPRS_HUMAN

host :

Synthetic

reactivity :

Human

sequence length :

1948

specificity :

PTPRS siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

purity :

> 97%

form :

Lyophilized powder

storage stability :

Shipped at 4 degree C. Store at -20 degree C for one year.

tested application :

RNA Interference (RNAi)

other info2 :

Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency. Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well). Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human PTPRS gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

products description :

siRNA to inhibit PTPRS expression using RNA interference

ncbi gi num :

104487006

ncbi acc num :

NP_002841.3

ncbi gb acc num :

NM_002850.3

uniprot acc num :

Q13332

ncbi mol weight :

168,394 Da

ncbi pathways :

ECM Proteoglycans Pathway (1270256); Extracellular Matrix Organization Pathway (1270244)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: integral to plasma membrane. Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity. Biological Process: corpus callosum development; extracellular matrix organization and biogenesis; spinal cord development; hippocampus development; cerebellum development; cerebral cortex development; cell adhesion

size1 :

15 nmol

price1 :

365 USD

size2 :

30 nmol

price2 :

515

more info or order :

MyBioSource product webpage