catalog number :
MBS820941
products full name :
Anti-Serpin B5 Antibody
products short name :
Serpin B5
products name syn :
PI5; Serpin B5; Maspin; Peptidase inhibitor 5; PI-5
other names :
serpin B5; Serpin B5; serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serpin peptidase inhibitor, clade B (ovalbumin), member 5; Maspin; Peptidase inhibitor 5; PI-5
products gene name :
SERPINB5
other gene names :
SERPINB5; SERPINB5; PI5; maspin; PI5; PI-5
uniprot entry name :
SPB5_HUMAN
reactivity :
Human, Mouse, Rat, Bovine
specificity :
Recognizes endogenous levels of Serpin B5 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
app notes :
WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)
ncbi acc num :
NP_002630.2
ncbi gb acc num :
NM_002639.4
ncbi mol weight :
25,763 Da
ncbi pathways :
ATF-2 Transcription Factor Network Pathway (138006); Direct P53 Effectors Pathway (137939); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
uniprot summary :
maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 18q21.33. Cellular Component: extracellular space; cytoplasm. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding. Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation