catalog number :
MBS8207935
products full name :
Anti-CD123 Antibody
products short name :
[CD123]
products name syn :
[IL3R; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123]
other names :
[interleukin-3 receptor subunit alpha isoform 2; Interleukin-3 receptor subunit alpha; interleukin-3 receptor subunit alpha; interleukin 3 receptor, alpha (low affinity); CD_antigen: CD123]
products gene name :
[IL3RA]
other gene names :
[IL3RA; IL3RA; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; IL3R; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA]
uniprot entry name :
IL3RA_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Recognizes endogenous levels of CD123 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD123. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to CD123
ncbi acc num :
NP_001254642.1
ncbi gb acc num :
NM_001267713.1
ncbi pathways :
ARMS-mediated Activation Pathway (1269471); Apoptosis Pathway (83060); Apoptosis Pathway (470); Axon Guidance Pathway (1270303); Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302)
ncbi summary :
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
uniprot summary :
IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3. Cellular Component: plasma membrane; integral to membrane. Molecular Function: interleukin-3 receptor activity