Anti-GSK3 beta Antibody | MyBioSource MBS8207657 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-GSK3 beta Antibody

catalog :

MBS8207657

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, zebrafish

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of GSK3 beta expression in MDA-MB-435 (A), Raw264.7 (B) whole cell lysates.

image 2 :

Immunohistochemical analysis of GSK3 beta staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

product information

catalog number :

MBS8207657

products type :

Antibody

products full name :

Anti-GSK3 beta Antibody

products short name :

[GSK3 beta]

products name syn :

[Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B]

other names :

[glycogen synthase kinase-3 beta isoform 2; Glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)]

products gene name :

[GSK3B]

other gene names :

[GSK3B; GSK3B; GSK-3 beta]

uniprot entry name :

GSK3B_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat, Bovine, Porcine, Sheep, Zebrafish

sequence length :

433

specificity :

Recognizes endogenous levels of GSK3 beta protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

tested application :

WB, IH, IP

app notes :

WB (1/500 - 1/1000). IH(1/100 - 1/200). IP (1/10 - 1/100)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

. Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GSK3 beta. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to GSK3 beta

ncbi gi num :

225903437

ncbi acc num :

NP_001139628.1

ncbi gb acc num :

NM_001146156.1

uniprot acc num :

P49841

ncbi pathways :

AKT Phosphorylates Targets In The Cytosol Pathway (1269189); AMER1 Mutants Destabilize The Destruction Complex Pathway (1268913); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1268909); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1268912); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1268910); Adaptive Immune System Pathway (1269171); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Androgen Receptor Signaling Pathway (198806)

ncbi summary :

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation. Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; GSK family; GSK subfamily. Chromosomal Location of Human Ortholog: 3q13.3. Cellular Component: nucleoplasm; centrosome; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic spine; dendritic shaft; beta-catenin destruction complex; nucleus; cytosol; ribonucleoprotein complex; lipid raft. Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; integrin binding; protein serine/threonine kinase activity; NF-kappaB binding; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding. Biological Process: circadian rhythm; glycogen metabolic process; fat cell differentiation; axon guidance; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; nerve growth factor receptor signaling pathway; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; positive regulation of cell-matrix adhesion; negative regulation of protein binding; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; response to drug; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of neuron maturation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage