catalog number :
MBS820708
products full name :
Anti-Cerebellin 1 Antibody
products short name :
Cerebellin 1
products name syn :
Cerebellin-1; Precerebellin
other names :
cerebellin-1; Cerebellin-1; cerebellin-1; precerebellin; cerebellin 1 precursor; PrecerebellinCleaved into the following 2 chains:Cerebellin; CER; [des-Ser1]-cerebellin
products gene name :
CBLN1
other gene names :
CBLN1; CBLN1; CER
uniprot entry name :
CBLN1_HUMAN
reactivity :
Human, Mouse, Rat, Bovine, Monkey, Pig
specificity :
Recognizes endogenous levels of Cerebellin 1 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000). Western blot analysis of Cerebellin 1 expression in HEK293T (A), SP2/0 (B), PC12 (C) whole cell lysates.
other info1 :
Entrez Gene: 869 (Human); 12404 (Mouse); 498922 (Rat). SwissProt: P23435 (Human); Q9R171 (Mouse); P63182 (Rat)
other info2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Cerebellin 1. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to Cerebellin 1
ncbi acc num :
NP_004343.1
ncbi gb acc num :
NM_004352.3
ncbi mol weight :
21,097 Da
ncbi summary :
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]
uniprot summary :
CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 16q12.1. Cellular Component: postsynaptic membrane; extracellular region; cell junction. Molecular Function: protein homodimerization activity. Biological Process: heterophilic cell adhesion; nervous system development; synaptic transmission; positive regulation of synaptogenesis; protein secretion; cerebellar granule cell differentiation