antibody

Anti-Beta-catenin (pS33) Antibody

MBS8206297

0.03 mL

165 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat, dog, cow

western blot, immunohistochemistry, immunocytochemistry

Antibody

Anti-Beta-catenin (pS33) Antibody

Beta-catenin

CTNNB; Catenin beta-1; Beta-catenin

catenin beta-1; Catenin beta-1; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa; Beta-catenin

CTNNB1

CTNNB1; CTNNB1; CTNNB; MRD19; armadillo; CTNNB

CTNB1_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat, Bovine, Dog, Porcine, Rabbit, Sheep

88

Recognizes endogenous levels of Beta-catenin (pS33) protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF (1/100 - 1/500), ICC (1/100 - 1/500)

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta-catenin (pS33). The exact sequence is proprietary.

Entrez Gene: 1499 (Human); 12387 (Mouse); 84353 (Rat). SwissProt: P35222 (Human); Q02248 (Mouse); Q9WU82 (Rat)

Rabbit polyclonal antibody to Beta-catenin (pS33)

148233338

NP_001091679.1

NM_001098209.1

P35222

9,501 Da

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (1270234); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); Apoptosis Pathway (1270262); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (1270290); Apoptotic Cleavage Of Cellular Proteins Pathway (1270288); Apoptotic Execution Phase Pathway (1270287); Arf6 Trafficking Events Pathway (137954)

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]

CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Protein type: Nuclear receptor co-regulator; Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein; Actin-binding; Transcription factor. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: centrosome; basolateral plasma membrane; intercellular junction; fascia adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; focal adhesion; tight junction; cell cortex; catenin complex; Z disc; nucleoplasm; adherens junction; apical part of cell; microvillus membrane; plasma membrane; cell junction; nucleus. Molecular Function: protein C-terminus binding; transcription coactivator activity; protein phosphatase binding; transcription factor binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; nitric-oxide synthase binding; SMAD binding; transcription factor activity; kinase binding; nuclear hormone receptor binding; alpha-catenin binding. Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; protein heterooligomerization; regulation of fibroblast proliferation; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell maturation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; osteoclast differentiation; cell-cell adhesion; positive regulation of endothelial cell differentiation; positive regulation of mesenchymal cell proliferation; regulation of cell fate specification; embryonic foregut morphogenesis; ectoderm development; male genitalia development; synapse organization and biogenesis; cell adhesion; bone resorption; response to drug; positive regulation of neuroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; hair cell differentiation; negative regulation of protein sumoylation; patterning of blood vessels; genitalia morphogenesis; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; dorsal/ventral axis specification; cell fate specification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; proximal/distal pattern formation; layer formation in the cerebral cortex; cell structure disassembly during apoptosis; negative regulation of mitotic cell cycle, embryonic; hair follicle morphogenesis; Wnt receptor signaling pathway; thymus development; in utero embryonic development; embryonic axis specification; stem cell maintenance; neural plate development; regulation of T cell proliferation; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; myoblast differentiation; negative regulation of oligodendrocyte differentiation; positive regulation of osteoblast differentiation; Schwann cell proliferation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; positive regulation of muscle cell differentiation; epithelial to mesenchymal transition; innate immune response; embryonic heart tube development; lens morphogenesis in camera-type eye; anterior/posterior axis specification. Disease: Pilomatrixoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Colorectal Cancer; Hepatocellular Carcinoma

0.03 mL

165 USD

0.1 mL

245

0.2 mL

350