protein

CD68 Blocking Peptide

MBS8205337

1 mg

160 USD

Blocking Peptide

CD68 Blocking Peptide

[CD68]

[Macrosialin; Gp110; CD68]

[macrosialin isoform B; Macrosialin; macrosialin; CD68 molecule; Gp110; CD_antigen: CD68]

[CD68]

[CD68; CD68; GP110; LAMP4; SCARD1]

CD68_HUMAN

Synthetic

Human, Mouse, Rat, Monkey

327

>85%

Lyophilized powder

Shipped at 4 degree C. Store at - 20 degree C for one year.

Blocking (BL)

Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

The peptide is used to block Anti-CD68 Antibody reactivity.

91199550

NP_001035148.1

NM_001040059.1

p34810

Lysosome Pathway (99052); Lysosome Pathway (96865)

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17p13. Cellular Component: membrane; lysosomal membrane; integral to membrane; plasma membrane; endosome membrane

1 mg

160 USD

5 mg

305