catalog number :
MBS820497
products full name :
Anti-MT-ND3 Antibody
products short name :
[MT-ND3]
products name syn :
[MTND3; NADH3; ND3; NADH-ubiquinone oxidoreductase chain 3; NADH dehydrogenase subunit 3]
other names :
[NADH dehydrogenase subunit 3 (mitochondrion); NADH-ubiquinone oxidoreductase chain 3; NADH dehydrogenase, subunit 3 (complex I); NADH dehydrogenase subunit 3; mitochondrially encoded NADH dehydrogenase 3; NADH dehydrogenase subunit 3]
products gene name :
[MT-ND3]
other gene names :
[MT-ND3; MT-ND3; MTND3; ND3; MTND3; NADH3; ND3]
uniprot entry name :
NU3M_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Recognizes endogenous levels of MT-ND3 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MT-ND3. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to MT-ND3
ncbi acc num :
YP_003024033.1
ncbi gb acc num :
NC_012920.1
ncbi pathways :
Electron Transport Chain Pathway (198860); Metabolic Pathways (132956); Metabolism Pathway (477135); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (413406); NADH:ubiquinone Oxidoreductase, Mitochondria Pathway (890440); Oxidative Phosphorylation Pathway (198870); Oxidative Phosphorylation Pathway (82942); Oxidative Phosphorylation Pathway (303); Parkinson's Disease Pathway (83098); Respiratory Electron Transport Pathway (160962)
uniprot summary :
MT-ND3: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND3 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ND3 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I subunit 3 family. Protein type: EC 1.6.5.3; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Mitochondrial; Energy Metabolism - oxidative phosphorylation. Chromosomal Location of Human Ortholog: -