Anti-Claudin 4 Antibody | MyBioSource MBS820456 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Claudin 4 Antibody

catalog :

MBS820456

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS820456

products type :

Antibody

products full name :

Anti-Claudin 4 Antibody

products short name :

Claudin 4

products name syn :

CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein

other names :

claudin-4; Claudin-4; claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein; claudin 4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein

products gene name :

CLDN4

other gene names :

CLDN4; CLDN4; CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; CPER; CPETR1; WBSCR8; CPE-R; CPE-receptor

uniprot entry name :

CLD4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Pig, Rabbit, Sheep

sequence length :

209

specificity :

Recognizes endogenous levels of Claudin 4 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB (1/500 - 1/1000), IH (1/100 - 1/200). Western blot analysis of Claudin 4 expression in DLD (A), SW480 (B), LS1034 (C), MIA (D), PaCa2 (E) whole cell lysates. Immunohistochemical analysis of Claudin 4 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Claudin 4. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Claudin 4

ncbi gi num :

4502877

ncbi acc num :

NP_001296.1

ncbi gb acc num :

NM_001305.4

uniprot acc num :

O14493

ncbi mol weight :

22,077 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Tight Junction Pathway (83071)

ncbi summary :

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

uniprot summary :

Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. Protein type: Membrane protein, integral; Cytoskeletal; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: tight junction; apicolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; basal plasma membrane; lateral plasma membrane. Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity. Biological Process: female pregnancy; signal transduction; response to progesterone stimulus; calcium-independent cell-cell adhesion

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage