Anti-IL-2 Antibody | MyBioSource MBS820434 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-IL-2 Antibody

catalog :

MBS820434

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of IL-2 expression in CTLL2 (A) whole cell lysates.

product information

catalog number :

MBS820434

products type :

Antibody

products full name :

Anti-IL-2 Antibody

products short name :

[IL-2]

products name syn :

[Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin]

other names :

[interleukin-2; Interleukin-2; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; interleukin 2; T-cell growth factor; TCGF; INN: Aldesleukin]

products gene name :

[IL2]

other gene names :

[IL2; IL2; IL-2; TCGF; lymphokine; IL-2; TCGF]

uniprot entry name :

IL2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

153

specificity :

Recognizes endogenous levels of IL-2 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-2. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to IL-2

ncbi gi num :

28178861

ncbi acc num :

NP_000577.2

ncbi gb acc num :

NM_000586.3

uniprot acc num :

P60568

ncbi mol weight :

17,628 Da

ncbi pathways :

AhR Pathway (755436); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Corticotropin-releasing Hormone Pathway (920957)

ncbi summary :

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

uniprot summary :

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Oncoprotein; Secreted, signal peptide; Cytokine; Secreted. Chromosomal Location of Human Ortholog: 4q26-q27. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; interleukin-2 receptor binding; kinase activator activity; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding. Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; cell-cell signaling; positive regulation of cell proliferation; protein kinase C activation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; immune response; negative regulation of B cell apoptosis; negative regulation of apoptosis; positive regulation of inflammatory response

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage