Anti-Cathepsin A 32k Antibody | MyBioSource MBS820402 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Cathepsin A 32k Antibody

catalog :

MBS820402

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of Cathepsin A 32k expression in HepG2 (A), mouse kidney (B), rat liver (C) whole cell lysates.

product information

catalog number :

MBS820402

products type :

Antibody

products full name :

Anti-Cathepsin A 32k Antibody

products short name :

[Cathepsin A 32k]

products name syn :

[PPGB; Lysosomal protective protein; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase]

other names :

[lysosomal protective protein isoform a; Lysosomal protective protein; lysosomal protective protein; deamidase; urinary kininase; carboxypeptidase C; carboxypeptidase L; carboxypeptidase-L; beta-galactosidase 2; lysosomal carboxypeptidase A; protective protein cathepsin A; carboxypeptidase Y-like kininase; beta-galactosidase protective protein; cathepsin A; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidaseCleaved into the following 2 chains:Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

products gene name :

[CTSA]

other gene names :

[CTSA; CTSA; GSL; GLB2; NGBE; PPCA; PPGB; PPGB; PPCA]

uniprot entry name :

PPGB_HUMAN

clonality :

Polyclonal

host :

unknown

reactivity :

Human, Mouse, Rat

sequence length :

498

specificity :

Recognizes endogenous levels of Cathepsin A 32k protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin A 32k. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to Cathepsin A 32k

ncbi gi num :

119395729

ncbi acc num :

NP_000299.2

ncbi gb acc num :

NM_000308.2

uniprot acc num :

P10619

ncbi mol weight :

52,489 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Asparagine N-linked Glycosylation Pathway (161013); Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway (161014); Glycosphingolipid Metabolism Pathway (530751); Immune System Pathway (106386); Lysosome Pathway (99052); Lysosome Pathway (96865); MHC Class II Antigen Presentation Pathway (645290); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

CTSA: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. Defects in CTSA are the cause of galactosialidosis (GSL). A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival. Belongs to the peptidase S10 family. Protein type: Endoplasmic reticulum; EC 3.4.16.5; Protease; Mitochondrial. Chromosomal Location of Human Ortholog: 20q13.1. Cellular Component: nucleoplasm; lysosomal lumen; membrane; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum. Molecular Function: serine carboxypeptidase activity; carboxypeptidase activity; enzyme activator activity. Biological Process: positive regulation of catalytic activity; intracellular protein transport; cellular protein metabolic process; sphingolipid metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; glycosphingolipid metabolic process; proteolysis; post-translational protein modification. Disease: Galactosialidosis

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage