antibody

Anti-mGLUR8 Antibody

MBS820400

0.03 mL

155 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

Anti-mGLUR8 Antibody

mGLUR8

GPRC1H; MGLUR8; Metabotropic glutamate receptor 8; mGluR8

metabotropic glutamate receptor 8 isoform a; Metabotropic glutamate receptor 8; metabotropic glutamate receptor 8; glutamate receptor, metabotropic 8

GRM8

GRM8; GRM8; GLUR8; mGlu8; GPRC1H; MGLUR8; GPRC1H; MGLUR8; mGluR8

GRM8_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat, Monkey, Pig, Rabbit

908

Recognizes endogenous levels of mGLUR8 protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

WB (1/500 - 1/1000). Western blot analysis of mGLUR8 expression in EOC20 (A), rat brain (B) whole cell lysates.

187960067

NP_000836.2

NM_000845.2

O00222

Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839); GPCRs, Other Pathway (198765); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

mGluR8: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q31.3-q32.1. Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity. Biological Process: negative regulation of cAMP biosynthetic process; regulation of synaptic transmission, glutamatergic; visual perception; sensory perception of smell; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

0.03 mL

155 USD

0.1 mL

220

0.2 mL

295