Anti-LIF Antibody | MyBioSource MBS820385 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-LIF Antibody

catalog :

MBS820385

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of LIF expression in Jurkat (A), NIH3T3 (B), PC12 (C) whole cell lysates.

product information

catalog number :

MBS820385

products type :

Antibody

products full name :

Anti-LIF Antibody

products short name :

[LIF]

products name syn :

[HILDA; Leukemia inhibitory factor; LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin]

other names :

[leukemia inhibitory factor isoform 2; Leukemia inhibitory factor; leukemia inhibitory factor; D factor; human interleukin in DA cells; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; differentiation-stimulating factor; differentiation inhibitory activity; leukemia inhibitory factor; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; INN: Emfilermin]

products gene name :

[LIF]

other gene names :

[LIF; LIF; CDF; DIA; HILDA; MLPLI; HILDA; LIF; D factor; MLPLI]

uniprot entry name :

LIF_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Bovine, Pig, Sheep

sequence length :

specificity :

Recognizes endogenous levels of LIF protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LIF. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to LIF

ncbi gi num :

380418324

ncbi acc num :

NP_001244064.1

ncbi gb acc num :

NM_001257135.1

uniprot acc num :

P15018

ncbi pathways :

Adipogenesis Pathway (198832); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Direct P53 Effectors Pathway (137939); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF Beta Signaling Pathway (198810)

ncbi summary :

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

uniprot summary :

LIF: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: extracellular space; cytoplasm. Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding. Biological Process: transcription from RNA polymerase II promoter; multicellular organismal development; leukemia inhibitory factor signaling pathway; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; negative regulation of meiosis; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of astrocyte differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; stem cell maintenance; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat1 protein; neuron development; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; immune response; alveolus development; embryo implantation

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage