Anti-MRP2 Antibody | MyBioSource MBS820348 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-MRP2 Antibody

catalog :

MBS820348

quantity :

0.03 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of MRP2 expression in HeLa (A), mouse brain (B), H9C2 (C) whole cell lysates.

product information

catalog number :

MBS820348

products type :

Antibody

products full name :

Anti-MRP2 Antibody

products short name :

[MRP2]

products name syn :

[CMOAT; CMOAT1; CMRP; MRP2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2]

other names :

[canalicular multispecific organic anion transporter 1; Canalicular multispecific organic anion transporter 1; canalicular multispecific organic anion transporter 1; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2]

products gene name :

[ABCC2]

other gene names :

[ABCC2; ABCC2; DJS; MRP2; cMRP; ABC30; CMOAT; CMOAT; CMOAT1; CMRP; MRP2]

uniprot entry name :

MRP2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1545

specificity :

Recognizes endogenous levels of MRP2 protein.

purity :

The antibody was purified by immunogen affinity chromatography.

form :

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB (1/500 - 1/1000)

image1 heading :

Western Blot (WB)

other info2 :

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MRP2. The exact sequence is proprietary.

products description :

Rabbit polyclonal antibody to MRP2

ncbi gi num :

4557481

ncbi acc num :

NP_000383.1

ncbi gb acc num :

NM_000392.4

uniprot acc num :

Q92887

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Codeine And Morphine Metabolism Pathway (198831); Drug Induction Of Bile Acid Pathway (698755); Irinotecan Pathway (198905); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10q24. Cellular Component: intercellular canaliculus; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane. Molecular Function: protein domain specific binding; protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding. Biological Process: prostaglandin transport; metabolic process; transport; response to heat; response to estrogen stimulus; response to arsenic; multidrug transport; response to oxidative stress; response to methotrexate; cellular chloride ion homeostasis; transmembrane transport. Disease: Dubin-johnson Syndrome

size1 :

0.03 mL

price1 :

155 USD

size2 :

0.1 mL

price2 :

220

size3 :

0.2 mL

price3 :

295

more info or order :

MyBioSource product webpage