product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-CLCN1 Antibody
catalog :
MBS820305
quantity :
0.03 mL
price :
155 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of CLCN1 expression in Hela (A), NIH3T3 (B), H9C2 (C) whole cell lysates.
product information
catalog number :
MBS820305
products type :
Antibody
products full name :
Anti-CLCN1 Antibody
products short name :
[CLCN1]
products name syn :
[CLC1; Chloride channel protein 1; ClC-1; Chloride channel protein, skeletal muscle]
other names :
[chloride channel protein 1; Chloride channel protein 1; chloride channel protein 1; clC-1; chloride channel 1, skeletal muscle; chloride channel protein, skeletal muscle; chloride channel, voltage-sensitive 1; Chloride channel protein, skeletal muscle]
products gene name :
[CLCN1]
other gene names :
[CLCN1; CLCN1; CLC1; CLC1; ClC-1]
uniprot entry name :
CLCN1_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
988
specificity :
Recognizes endogenous levels of CLCN1 protein.
purity :
The antibody was purified by immunogen affinity chromatography.
form :
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB (1/500 - 1/1000)
image1 heading :
Western Blot (WB)
other info1 :
Entrez Gene: 1180 (Human); 12723 (Mouse); 25688 (Rat). SwissProt: P35523 (Human); Q64347 (Mouse); P35524 (Rat)
other info2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CLCN1. The exact sequence is proprietary.
products description :
Rabbit polyclonal antibody to CLCN1
ncbi gi num :
119433677
ncbi acc num :
NP_000074.2
ncbi gb acc num :
NM_000083.2
uniprot acc num :
P35523
ncbi mol weight :
108,626 Da
ncbi pathways :
Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); Transmembrane Transport Of Small Molecules Pathway (106572)
ncbi summary :
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
uniprot summary :
CLCN1: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN1 are the cause of Thomsen disease (THD); also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy. Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR); also known as Becker disease. Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily. Protein type: Transporter; Channel, chloride; Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 7q35. Cellular Component: integral to plasma membrane; plasma membrane; sarcolemma. Molecular Function: chloride channel activity; voltage-gated chloride channel activity. Biological Process: muscle contraction; transport; action potential propagation; transmembrane transport. Disease: Myotonia Congenita, Autosomal Recessive; Myotonia Congenita, Autosomal Dominant
size1 :
0.03 mL
price1 :
155 USD
size2 :
0.1 mL
price2 :
220
size3 :
0.2 mL
price3 :
295
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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